In support of the later model, we and others have uncovered critical roles of MYC and MYCN in maintaining the genomic stability of tumour cells, e.g., by coordinating transcription with DNA replication and by enabling promoter-proximal double-strand break repair (Baluapuri et al., 2020; Papadopoulos et al., 2023). The gene discussed is MYC; the disease is neoplasm.