IFNG and colitis: In contrast, Gonçalves et al. reported that allogeneic ADSCs administered intravenously to mice with DSS-induced colitis induced high levels of IFN-γ in mouse serum, thereby activating the immunomodulatory function of ADSCs and showing increased T-cell apoptosis in the inflamed colon and improvement of inflammation, although this did not occur upon intraperitoneal administration (47).