Consistent with the above studies, priming of cADSCs with a combination of TNF-α and IFN-γ in this study drastically enhanced the capacity of cADSCs to induce M2 macrophages and Treg cells, suppress Th1/Th17-cell responses, and inhibit Th-cell proliferation, thereby reducing the severity of colitis, with the upregulation of COX-2 and TSG-6 (Supplementary Table 1). This evidence concerns the gene TNF and colitis.