We used the following search terms: "lipid-lowering," “cholesterol-lowering," “statins," "fibrates," “PCSK9 inhibitors," "ezetimibe," “bile acid sequestrants," “bempedoic acid," “omega-3 fatty acids," and "hyperlipidemia." We focused on the clinical trials and systematic reviews discussing the comparative effectiveness of different lipid-lowering agents and provided insights into their safety considerations, drug interactions, and contraindications. The gene discussed is PCSK9; the disease is hyperlipidemia.