According to the MR analysis, we found that C-C motif chemokine 19 (CCL19), C-C motif chemokine 28 (CCL28), TNF-related apoptosis-inducing ligand (TRAIL), and vascular endothelial growth factor A (VEGF-A) levels were associated with an increased risk of sepsis-related outcomes. The gene discussed is VEGFA; the disease is Sepsis.