Similar results have been obtained in studies evaluating high-grade pancreatic ductal adenocarcinomas, renal cell carcinomas, and hepatic carcinomas.(33) Another research group has also reported this association between IMP3 expression and high-grade endometrial neoplasms.(34) We further determined associations between the extent and intensity of IMP3 staining and cases of SC, indicating its potential for distinguishing between different subtypes. This evidence concerns the gene IMP3 and hereditary clear cell renal cell carcinoma.