In our previous work, 897 differentially expressed genes were revealed by using RNA sequencing (RNA-seq) between IM-sensitive and IM-resistant GIST cell lines, and further investigation indicated that COL4A1, FABP4, and RGS4 may play a potential role in the clinical treatment of IM resistance in GIST.91 The gene discussed is RGS4; the disease is gastrointestinal stromal tumor.