SDHB and neoplasm: Additionally, the accumulation of reactive oxygen species, which are mainly produced in complex I and complex III in ETC is reported to has important consequences for the loss of function of the SDH, their relationship is also considered to be implicated in tumor pathogenesis.115Recently, some scholars have proposed that SDH knockdown increases intracellular levels of succinate, by which a-KG dependent dioxygenases, JIp1, which is involved in sulfur metabolism and Jhd1, which belongs to the JmjC-domain containing histone demethylase enzymes were inhibited.