Regarding exon 17, the 70% of mutations is Asn822Tyr, these tumors arise frequently in the small intestine and usually present a spindle cell morphology.2, 30Asp820Tyr mutation is also detected previously, and Arima et al present the case of a patient with multiple GISTs with a novel germline KIT gene mutation (Asp820Gly) in exon 17.2Furthermore, mutations in exon 8 occur rarely in GIST. Here, KIT is linked to gastrointestinal stromal tumor.