In a recent study, the concomitant occurrence of BRAF/KIT and BRAF/PDGFRA mutations in GISTs is confirmed by using a quantitative competitive allele-specific Taq-Man duplex polymerase chain reaction.139Accordingly, two spindle cell phenotype GIST cases harboring novel BRAF fusion genes arising in two young–adult women in the small bowel and esophagus have been reported. The gene discussed is BRAF; the disease is gastrointestinal stromal tumor.