Next, we acquired the top 10 PPA2-correlated genes from all TCGA tumors and normal tissues, among these genes, LAMTOR3, CDS1, EIF4E, LRBA, PLA2G12A, and ARFIP1) showed high correlations (all r>0.05,p<0.05)with PPA2 (Figure 5B); in addition, the Timer database showed that these genes (CDSA, EIF4E, LRBA PLA2G12A, and ARFIP1) are closely related to PPA2 in the majority of cancer types (Figure 5C). This evidence concerns the gene EIF4E and cancer.