Compared with those having the reference genotype in a dominant genetic model, NSCLC patients had a significantly poor survival associated with INPP5D rs13385922 CT+TT (OS: HR = 1.22, 95% CI = 1.06-1.42, and P = 0.008; DSS: HR = 1.29, 95% CI = 1.10-1.51, and P = 0.002), and with EXOSC3 rs3208406 AG+GG (OS: HR = 1.27, 95% CI = 1.05-1.55, and P = 0.015; DSS: HR = 1.37, 95% CI = 1.12-1.67, and P = 0.002). The gene discussed is EXOSC3; the disease is non-small cell lung carcinoma.