IL1B and central nervous system disorder: Consequently, astrocyte-derived exosomes serve as pivotal “communication messengers” in central nervous system diseases (28, 29).The intervention of astrocyte-derived exosomes in the presence of the inflammatory factor IL-1β enhances neuronal uptake of astrocyte-derived exosomes, suggesting that inflammatory conditions may facilitate intercellular communication between astrocyte-derived exosomes and neurons (30).