Similarly, ANGPTL4 protein level was elevated in in T2D patients (6 times higher, p=0.001), OA patients (3.6 times higher, p=0.036), and T2D+OA patients (10 times higher, p < 0.001) compared to the healthy group (Figures 5D, E). The gene discussed is ANGPTL4; the disease is type 2 diabetes mellitus.