On the other hand, immune and inflammatory responses, hemostatic and thrombotic processes, and infections were also involved in the URPL pathway, for instance, CD22-mediated B-cell receptor (BCR) regulation, antigen activating BCR leading to generation of second messengers, cell surface interactions at the vascular wall, binding and uptake of ligands by scavenger receptors, and role of phospholipids in phagocytosis. The gene discussed is CD22; the disease is infection.