In return, lncRNA-SARCC expression can be transcriptionally regulated by HIF-2α through its binding to hypoxia-responsive elements on the lncRNA-SARCC promoter, suggesting the presence of a negative feedback loop.135 These findings provide valuable insights into the role of lncRNA-SARCC as a suppressor of RCC progression and highlight new therapeutic strategies for the treatment of RCC, specifically focusing on the regulation of AR and miRNA interactions. The gene discussed is EPAS1; the disease is renal cell carcinoma.