In return, lncRNA-SARCC expression can be transcriptionally regulated by HIF-2α through its binding to hypoxia-responsive elements on the lncRNA-SARCC promoter, suggesting the presence of a negative feedback loop.135 These findings provide valuable insights into the role of lncRNA-SARCC as a suppressor of RCC progression and highlight new therapeutic strategies for the treatment of RCC, specifically focusing on the regulation of AR and miRNA interactions. Here, AR is linked to renal cell carcinoma.