HOTAIR and renal cell adenocarcinoma: Analysis of the ccRCC patient survival data from the Cancer Genome Atlas indicates worse overall survival (OS) for patients with elevated ER-β and FN1 expression, while higher miRNA-204-3p expression correlates with significantly better OS, emphasizing the clinical relevance of the ER-β/circATP2B1/miRNA-204-3p/FN1 axis in ccRCC progression.116 Furthermore, ER-β facilitates an increase in HOTAIR expression by binding to its promoter in RCC.