Interaction with this mechanism by different signal molecules like AR, ER, PR and their ligands causes activation or inactivation of downstream signalling components.58,59 Here, we present evidence strongly suggesting that the interplay between the SH axis and signalling pathways implicated in oncogenesis, observed in other cancer types, may also have relevance in the development of RCC (Table 1). This evidence concerns the gene PGR and renal cell adenocarcinoma.