High-grade RCC patients exhibited a higher degree of neutrophil infiltration in tumour tissue compared to low grade, indicating the potential role of cancer-induced immunosuppression in promoting cancer progression through the modulation of neutrophils.90 Focusing on N2 neutrophils, which are known to be involved in carcinogenesis, angiogenesis and immunosuppression, Song et al.62 described their ability to promote RCC proliferation by upregulating AR expression via the AR-c-Myc signalling pathway. This evidence concerns the gene AR and renal cell adenocarcinoma.