EPAS1 and renal cell adenocarcinoma: Interestingly, the authors observed that Sunitinib induces the expression of lncRNA-SARCC, thereby reducing the resistance of RCC cells to this drug.134 An additional suppressive effect of LncRNA-SARCC on RCC development could be revealed through its regulation of the AR/HIF-2α/C-MYC axis signalling pathway.