Even though the efficacy of Cornea‐S1 and Cornea‐S2 liposomes in managing dry eye conditions was similar to that of the S2.2 mucin aptamer functionalized liposomes, Cornea‐S1 and Cornea‐S2 aptamers had lower Kd values compared to S2.2 aptamer. The gene discussed is MUC5AC; the disease is dry eye syndrome.