GZMB and neoplasm: The cleavage of IEPDVSVQ linker by granzyme B released a radiolabeled form of Temporin L, which sequestered radioisotope through binding to adjacent tumor cell phospholipid bilayers, whose tissue biodistribution in the body reflected the relative unit of granzyme B activity, hence realizing measurement of granzyme B and T cells activation with immune checkpoint inhibitors (CPI) (Figure 7B).[28]