As a member of the matrix metalloproteinases (MMPs) family, matrix metalloproteinase‐2 (MMP‐2) or matrix metalloproteinase‐9 (MMP‐9), is overexpressed in a variety of tumors and associated with tumor development, invasion, and metastasis.[57] They are significant tumor biomarkers and activatable imaging probes are developed accordingly for tumor progression diagnosis. This evidence concerns the gene MMP2 and neoplasm.