For example, H2O2‐responsive borate linker and tyrosinase (TYR)‐responsive 3‐hydroxybenzyloxy linker were reported to construct a dual‐locked near‐infrared fluorescent probe (MB‐m‐borate) for diagnosis of melanoma.[29] The locking borate and 3‐hydroxybenzyloxy linkers could be cleaved by high level of H2O2 and tyrosinase in melanoma cells, respectively, resulting in the nonfluorescent MB‐m‐borate to generate fluorophore methylene blue (MB) which could emit NIR fluorescence with a wavelength of 684 nm. The gene discussed is TYR; the disease is melanoma.