Sirtuin 3 (SIRT3), a nuclear‐encoded NAD+‐dependent deacetylase, is predominantly found in the mitochondrial matrix and plays a crucial role in multiple cellular processes, including the tricarboxylic acid cycle, fatty acid β‐oxidation and antioxidant pathways.[28] Excessive oxidative stress and mitochondrial damage can lead to decreased SIRT3 levels in tubular cells rich in mitochondria, contributing to acute kidney injury. This evidence concerns the gene SIRT3 and acute kidney injury.