SUV39H2 is involved in histone methylation (H3-K9 specific) and chromatin assembly (Padeken et al., 2022) and is linked to colorectal cancer proliferation and metastasis (Shuai et al., 2018), but its function in NB has yet to be clarified (Tong et al., 2013). This evidence concerns the gene SUV39H2 and neuroblastoma.