TF and cancer: We next investigated a total of 1,113 NB-dependent EP-TF genes, guided by three main criteria: 1) significantly upregulation in HR-NB tumor tissues (GSE12460, GSE13136 and GSE16476) as compared to normal adrenal gland tissues (GSE3526, GSE7307 and GSE8514) in the GEO datasets (Supplementary Figures S2A–D); 2) significantly upregulation in 24 NB cell lines (GSE28019) versus neural crest cells (GSE14340) in the GEO datasets (Supplementary Figure S2E); and 3) highest expression in NB from a pan-cancer viewpoint according to the cancer cell encyclopedia dataset (Supplementary Figure S2F).