IFNA1 and systemic lupus erythematosus: For instance, a former study unveiled that m5C methylation levels and NSUN2 expression were reduced in CD4+ T cells of patients with systemic lupus erythematosus and that m5C hypermethylation was closely associated with immune- and inflammation-related diseases, such as systemic lupus erythematosus, via pathways including the immune system, cytokine signaling, and IFN signaling (Guo et al., 2020).