Among these, several that were upregulated during infection, including the WNT signaling regulator, adenomatous polyposis coli,27 APC S2129; the actin binding protein twinfilin,28 A6R Y309; the Abelson murine leukemia viral oncogene, Arg Y439 + T440; and the cAMP-responsive element binding protein 1, CREB1 S129 + S133, were downregulated by treatment in the GSK3β CRISPR KO and in THP-1 cells infected with the ΔptpA mutant (Figures 4C and 4D). Here, CREB1 is linked to infection.