COPA and lung carcinoma: Among the risk factors, the tumor-promoting gene COPA (coatomer protein subunit alpha) plays a crucial role in vesicle trafficking within the Golgi apparatus and retrograde transport of cargo proteins between the endoplasmic reticulum (ER) and Golgi, potentially influencing the autoinflammatory process by modulating type I interferon signaling, which has been involved in the pathophysiology of lung cancer (Lepelley et al., 2020; Bao et al., 2022).