SNP rs17713054 SLC6A20-LZTFL1 was associated with an increased risk of severe COVID-19 risk among nonsmokers (risk allele A; OR = 1.65, 95% CI = 1.11–2.46, p = 0.02), patients with low fruit and vegetable intake (OR = 1.72, 95% CI = 1.15–2.58, p = 0.01, pbonf = 0.02), and patients with low levels of physical activity (OR = 1.93, 95% CI = 1.26–2.94, p = 0.0035, pbonf = 0.007) (Supplementary Table S6). Here, LZTFL1 is linked to COVID-19.