In the present study, we replicated associations of the rs17713054 SLC6A20-LZTFL1, rs17078346 SLC6A20-LZTFL1, rs12610495 DPP9 and rs7949972 ELF5 with severe COVID-19 within the Caucasian population of Central Russia. The gene discussed is ELF5; the disease is COVID-19.