PBX2 and cancer: Among cancer traits, in addition to the highly pleiotropic genes in clusters 1-4, JIA has a unique association with “nodular sclerosis Hodkin lymphoma” through a subset of genes in cluster 8 (FKBPL, PBX2, AGER; Figure 5e) and with “chronic lymphocytic leukemia” through the BAK1 gene in cluster 6 (Figure 5d).