TIMD4 and metabolic dysfunction-associated steatotic liver disease: In addition, the presence of TIM-4 on KCs acts as a negative regulator, reinstating autophagy through the Akt4/mitophagy signaling pathway and modulating the progression of NAFLD by exerting inhibitory effects on the NLRP1 inflammasome via the LKB3/AMPKα pathway (181, 182).