In addition, first-trimester preeclampsia screening using a combination of maternal risk factors, mean arterial pressure (MAP), uterine artery pulsatility index (PI), and maternal serum PAPP-A and placental growth factor (PLGF) levels has been demonstrated to achieve 93% and 36% detection rates for early-onset and late-onset preeclampsia, respectively (7). This evidence concerns the gene PAPPA and preeclampsia.