It has been shown to increase the Bax/Bcl-2 ratio, an indicator of increased apoptosis index, and to promote apoptosis in colorectal cancer cells (62–64) In summary, the gut microbiota generates a variety of metabolites that exhibit anti-tumor activity through the inhibition of tumor cell proliferation, the regulation of tumor cell apoptosis, and the suppression of inflammatory responses. Here, BAX is linked to neoplasm.