PKM and melanoma: We found that in all melanoma cell lines, the protein expression of the glycolytic markers glucose transporter (GLUT) 3, mediating glucose uptake from the extracellular environment, hexokinase (HK) 2, a critical enzyme catalyzing the first rate-limiting step of glycolysis and pyruvate kinase M2 (PKM2), gradually decreases as the steps in rocking condition progress from S to p3-S (Figures 3A, C, E).