Research on animals has shown that honeysuckle can control the NF-κB signaling pathway in acne sufferers, which in turn can control the serum levels of IL-1β and TNF-α as well as the levels of intracellular NF-κB65, IKK-α, and IKK-β egg white Li et al., 2019. Here, NFKB1 is linked to acne.