In V90, during the inpatient study, one of three cases of myelitis (33%) was antiaquaporine-4 (AQ4) antibody positive and had a longitudinally extensive lesion on MRI, with a suspected diagnosis of Neuromyelitis optica spectrum disorder; another case had positive ANA antibodies (and no diagnostic criteria of systemic autoimmune disorders). This evidence concerns the gene BTG3 and neuromyelitis optica.