The up-regulation of some transcription factors and mediators such as CD138, BCL-2, NF-κB, STAT3 and retinoic acid receptor (RAR), is known to thwart cell death in MM, thereby contributing to resistance and evasion of programmed cell death (PCD) pathways including ferroptosis, apoptosis, pyroptosis, and autophagic cell death (Wang et al., 2009; Kim et al., 2017; Guo et al., 2021). This evidence concerns the gene NFKB1 and Miyoshi myopathy.