OPRM1 and neuropathic pain: Additionally, buprenorphine’s unique receptor binding properties may be able to provide an analgesic effect without the high risk of abuse and tolerance seen with other opioids (Davis et al., 2018) Similarly, Infantino et al. elaborate on buprenorphine’s distinct pharmacological actions, such as its biased agonism at mu-opioid receptors and high affinity for opioid-like receptor 1, which contribute to its effectiveness in neuropathic pain, a condition often resistant to traditional opioids (Infantino et al., 2021).