INS and obesity due to melanocortin 4 receptor deficiency: Interestingly, results from two recent meta-analyses comprising over 50 randomized controlled trials comparing the effect of CR and IF interventions for a median period of 2–3 months revealed similar effects in subjects with overweight and obesity in terms of body weight (and composition), plasmatic lipid profile, or insulin resistance improvements (Gu et al., 2022; Ezzati et al., 2023).