PARP1 and acute myeloid leukemia: Sequence data demonstrate that PARP family genes alteration is rare in patients with AML; however, mutations and copy number alterations of DDR genes, such as, ATM, ATR, CHEK1, CHEK2, RAD51, and PALB2, have been detected, leading to HR pathway dysregulation in patients with AML (cBioPortal for Cancer Genomics.