The first is that AML blasts can inhibit the expression of antigen presentation molecules and overexpress immune inhibitory molecules, such as PD-L1 and Cal-9 (Kikushige et al., 2010; Kikushige and Miyamoto, 2015; Taghiloo and Asgarian-Omran, 2021). This evidence concerns the gene CD274 and acute myeloid leukemia.