In addition, CUR has demonstrated its unique efficacy in the treatment of osteoarthritis by precisely intervening in the PI3K-AKT signaling pathway, which protects joint health by inhibiting the PI3K/AKT/mTOR signaling cascade, promoting autophagic response, reducing joint inflammation and restoring joint homeostasis (Song et al., 2022). The gene discussed is AKT1; the disease is osteoarthritis.