CYP11B1 and Adrenal insufficiency: This is different for the potent CYP11B1 inhibitors posaconazole and itraconazole where cases with adrenal insufficiency and hyperplasia have been described, mainly due to cross-reactions with other drugs depending on functional CYP3A4 or in combination with unrelated diseases (Skov et al., 2002; Molimard et al., 2008; Miller et al., 2018; Pimentel et al., 2018; Araque et al., 2020).