Due to the feedback response, inhibition of CYP11B1 results in an accumulation of the CYP21A2 products 11-deoxycorticosterone (11-DOC) and cortexolone (11-deoxycortisol), which are moderate MR agonists but at elevated levels can cause pseudohyperaldosteronism with hypertension and hypokalemia (Funder, 2007). The gene discussed is NR3C2; the disease is hypertensive disorder.