ESR1 and insomnia measurement: During an in silico study where the anti-insomnia mechanism of EAHMs was investigated, including this botanical drug (i.e., the Suan Zao Ren Prescription), the researchers found that most of the EAHMs exert broad hormone-regulating effects by targeting estrogen receptors, progesterone receptors, and adrenergic receptors (Gao et al., 2019).