A recent study in non-small-cell lung cancer (NSCLC) cells showed that ERβ promotes invasion by directly binding to and inducing the expression of TMX4 circular RNA, which, through the inhibition of miR-622, leads to upregulation of the G protein-coupled receptor (GPCR) CXCR4 that promotes metastasis in several types of cancer [53]. This evidence concerns the gene ESR2 and non-small cell lung carcinoma.