GoF variants in KCNQ2 and KCNQ3 genes were recently reported to cause profound developmental delay, neonatal non-epileptic myoclonus, and later-onset epilepsy such as infantile spasms or the autism phenotype with no clinical seizures, respectively (Miceli et al., 2015; Millichap et al., 2017; Mulkey et al., 2017; Sands et al., 2019; Miceli et al., 2022). The gene discussed is KCNQ2; the disease is infantile spasms.