KCNQ2-linked pathogenic variants include a range of overlapping neonatal epileptic phenotypes ranging from mild self-limited familial neonatal epilepsy to severe neonatal-onset developmental and epileptic encephalopathy (Miceli et al., 1993; Biervert et al., 1998; Singh et al., 2003; Weckhuysen et al., 2012). This evidence concerns the gene KCNQ2 and developmental and epileptic encephalopathy.