ACHE and early-onset autosomal dominant Alzheimer disease: In this translational project, we investigated whether the cholinergic drug donepezil, an inhibitor of the brain acetylcholinesterase widely used in Alzheimer’s disease (Bryson and Benfield, 1997), can act as an indirect Kv7 channel blocker in vitro by increasing the cholinergic tonus and thus improving cognitive symptoms in patients with GoF variants in the KCNQ2 and KCNQ3 genes.