Meta-analysis of randomized effect model showed that compared with PN group, the transferrin level of esophageal cancer patients in MN group was higher on the 7th day after operation, and the difference between the two groups was statistically significant [MD = 0.60, 95% CI (0.29, 0.91), P = 0.0002]. The gene discussed is TF; the disease is esophageal cancer.