TNF and neoplasm: Although the pathophysiology of these syndromes is beyond the scope of this paper, it has been demonstrated that tumor cell destruction following CAR T-cell activation results in a drastic surge in the levels of inflammatory cytokines [interferon-γ, tumor necrosis factor-α (TNF-α), granulocyte-macrophage colony-stimulating factor, interleukin (IL)-10, IL-6 and others].