CD63 and hepatocellular carcinoma: Recently, a portable SPR sensor study was conducted thatwas modified with three different layers consisting of Au mirror/SiO2 spacer/Au nanohole to enhance sensitivity.140 EpCAM and CD63 aptamers were immobilized on the sensorsurface to separate HepG2 hepatocellular carcinoma cells and L02 healthy-cell-derivedEVs.