CD63 and cancer: Thisrecognition underscores the essential role of EVs in facilitatingintercellular communication and their significance in various physiologicaland pathological processes.6−8 Moreover, given that EVs are reflectiveof their originating cells, they actively participate in both normalphysiological processes and pathological conditions, including cancerprogression and metastasis.9,10 While universal EVsurface proteins such as CD9, CD63, and CD81 are widely recognized,cancer-derived EVs can harbor specific proteins indicative of theirmalignant origin.