Sclerostin was expressed in 3D constructs that activated the nuclear factor κ B/osteoprotegerin (RANK/OPG) pathway of prostate cancer cells, affecting the nuclear factor κ B/osteoprotegerin (RANK/OPG) pathway of prostate cancer cells, affecting the nuclear factor κ B/osteoprotegerin (RANK/OPG) pathway of prostate cancer cells affecting metastasis. The gene discussed is SOST; the disease is Familial prostate cancer.