The generation of mature collagen fiber cross-linksis facilitated by the action of enzymes such as lysyl oxidase (LOX)and lysyl hydroxylases (LH).40 This canalso lead to robust stiffening and enhanced behavior of the tumors.For example, Hylald-derived collagen cross-linking caused stromalstiffening, tissue fibrosis, and regulated breast tumor aggressionin triple-negative (TN) subtype.41 Here, LOX is linked to breast neoplasm.