Some researchers have observed that CAR-M not only functioned as antigen-presenting cells that present tumor antigens to prime T cells, but also increased intratumoral infiltration of tumor infiltrating cells, such as antitumoral neutrophils, Th1, Th17, cytotoxic T cells (CTL) and NK cells by secreting CXCL8, CXCL9, CXCL10, CXCL11 and CCL5 [1] (Fig. 2c). This evidence concerns the gene CCL5 and neoplasm.