Epigenetic DNA methyltransferase (DNMT) inhibitor 5-Azacytidine (AZA) and an ornithine decarboxylase (ODC) inhibitor α-difluoromethylornithine (DFMO) in combination dramatically reduced the number of M2-polarized macrophages and increased tumor-killing M1 macrophages, which significantly reduced tumor burden and prolonged survival [45]. Here, ODC1 is linked to neoplasm.