12 of the targeting sex-biased genes (S100A9, SLAMF7, TNFRSF17, CCND1, CD274, TOP2A, HTR2B, CD3D, SSTR2, ORM2, ORM1, TNF) have been reported previously as cancer therapeutic targets (Fig. 6C, Supplementary Fig. S8,Supplementary Table S7). This evidence concerns the gene ORM2 and cancer.