12 of the targeting sex-biased genes (S100A9, SLAMF7, TNFRSF17, CCND1, CD274, TOP2A, HTR2B, CD3D, SSTR2, ORM2, ORM1, TNF) have been reported previously as cancer therapeutic targets (Fig. 6C, Supplementary Fig. S8,Supplementary Table S7). Here, CD274 is linked to cancer.