TOP2A and cancer: 12 of the targeting sex-biased genes (S100A9, SLAMF7, TNFRSF17, CCND1, CD274, TOP2A, HTR2B, CD3D, SSTR2, ORM2, ORM1, TNF) have been reported previously as cancer therapeutic targets (Fig. 6C, Supplementary Fig. S8,Supplementary Table S7).