12 of the targeting sex-biased genes (S100A9, SLAMF7, TNFRSF17, CCND1, CD274, TOP2A, HTR2B, CD3D, SSTR2, ORM2, ORM1, TNF) have been reported previously as cancer therapeutic targets (Fig. 6C, Supplementary Fig. S8,Supplementary Table S7). The gene discussed is HTR2B; the disease is cancer.