Anti-Ro-52 antibodies are frequently identified in the serum of patients suffering from a range of autoimmune disorders, including but not limited to primary Sjögren’s syndrome, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), mixed connective tissue disease (MCTD), myositis, autoimmune hepatitis, and primary biliary cirrhosis [15]. The gene discussed is TRIM21; the disease is mixed connective tissue disease.