TRIM21 and congenital heart block: Based on evidence that anti-Ro-52 antibodies may play a direct pathogenic role in congenital heart block in neonatal lupus and that these antibodies from patients with primary Sjögren’s syndrome inhibit the E3 ligase activity of the Ro-52 protein, it is postulated that these autoantibodies might exacerbate proinflammatory signals mediated by type 1 interferons.