For the modifying effect of the Cx37 gene, ORI was positively and moderately associated with a history of hypertension and RLPC in CC homozygotes (p = 0.02 and p = 0.02, respectively) and inversely and moderately associated with female sex (p = 0.05). More detailed data are available in the Supplementary material (Tables 8 and 9). The gene discussed is GJA4; the disease is Hypertension.