No modifying effect of the Cx37 gene polymorphism was detected The uACR (Fig. 3a) was positively and strongly associated with female sex, duration of diabetes, HbA1c, history of hypertension, pulse pressure, AIP and FIB-4 and moderately associated with RLPC, Lp(a) and CC homozygosity (p = 0.003, p = 0.01, p < 0.001, p < 0.001, p = 0.004 p < 0.001 and p = 0.01, and p = 0.02, p = 0.02 and p = 0.02, respectively), and it was inversely and strongly associated with body fat (p < 0.001). The gene discussed is GJA4; the disease is Hypertension.