STAT3 is a well-known transcription factor that plays important roles in many kind of cell survival, proliferation, and migration.30–32 Dysregulation of STAT3 signaling has been implicated in the development and progression of many cancers, including lung cancer.33, 34 Therefore, our findings suggest that ROP16 may be involved in the regulation of STAT3 signaling in lung adenocarcinoma cells. The gene discussed is STAT3; the disease is lung adenocarcinoma.