CD274 and neoplasm: Immunotherapy has become another therapeutic method that can improve the sensitivity of the body’s immune system to tumor cells and kill them specifically.5 Promising prospects have been observed for immune checkpoint inhibitors such as programmed death receptor 1 (PD-1)/programmed death ligand (PD-L1) inhibitors.6–8 However, further research is needed to address issues such as hyperimmune response, pseudoprogression, and the complexity and diversity of tumor microenvironments.