ARID1A has been recognized as a tumor suppressor (Li et al, 2017; Shi et al, 2020), while disrupting the canonical SWI/SNF complex structure through the silencing of both ARID1A and ARID1B has been found to inhibit the growth and metastasis of NB (Jimenez et al, 2022). The gene discussed is SMARCA1; the disease is neuroblastoma.