In NB, core TFs including MYCN, HAND2, PHOX2B, and GATA3 cooperatively regulate the transcriptional profile that defines the ADRN-type of NB (Boeva et al, 2017; Durbin et al, 2018; van Groningen et al, 2017; Xu et al, 2023). This evidence concerns the gene PHOX2B and neuroblastoma.