MYCN and neuroblastoma: MYCN amplification occurs in over 20% of NB patients, with MYCN playing a pivotal role as an oncogenic driver that significantly contributes to uncontrolled NB growth and metastasis (Huang and Weiss, 2013; Liu et al, 2020a; Otte et al, 2020; Teitz et al, 2013; Weiss et al, 1997; Zhu et al, 2017).