It should also be emphasized that high MSLN expression, especially in MSS patients, was associated with significantly increased IHC-PD-L1 staining (Fig. 3B) and enhanced gene expression of PD-1, CTLA4, FOXP3, LAG3, and TIM3 (Fig. 4B). The gene discussed is HAVCR2; the disease is Marinesco-Sjogren syndrome.