TREM2 and Alzheimer disease: AL002 (27) is a TREM2-specific monoclonal antibody that activates TREM2 to enhance microglial function, thereby reducing Aβ plaque formation and attenuating neurite dystrophy.474 A phase II study (NCT04592874) is currently underway to evaluate the efficacy and safety of AL002 (27) in participants with early-stage AD.