Their shared scaffold may offer new insights for casein kinase 1δ (CK1δ) inhibitor development.515 In AD, c-Jun N-terminal kinase3 (JNK3) activation is closely associated with neuronal damage, amyloid deposition, and the formation of tau tangles.516 Hah et al. have conducted in-depth studies on this target, continuously refining and developing several generations of compounds based on the structure of pan-JNK inhibitor 42, which was identified through an in-house kinase-focused library screening. The gene discussed is MAPK8; the disease is Alzheimer disease.