The objective of this study is to confirm the efficacy of masitinib (28) as an adjunct therapy to cholinesterase inhibitors and/or memantine (7) in improving cognitive and functional abilities in patients with mild to moderate AD.476 Repurposed drugs include nilvadipine (29), a calcium channel blocker for the treatment of hypertension, and pioglitazone (30), a drug initially developed for diabetes. This evidence concerns the gene BCHE and Alzheimer disease.