Carrying one or two APOE ε4 alleles increases the risk of AD by 2-3 and 12-fold, respectively.118 Research indicates that APOE protein is detectable in neuritic plaques, and individuals with the APOEε4 allele also have a higher burden of Aβ plaques in their brains,119,120 highlighting its critical influences on Aβ deposition. The gene discussed is APOE; the disease is Alzheimer disease.