MAPT and Alzheimer disease: Protein-protein interactions (PPIs) are fundamental in maintaining cellular functions, while aberrant interactions between proteins are implicated in the pathogenesis of numerous diseases.75,579 For instance, AD is characterized by the misfolding and aggregation of Aβ and tau proteins, involving a variety of molecular mechanisms and complex networks of PPIs.580–582 Thus, disrupting these interactions may block some critical signaling pathways and potentially mitigate the pathological process of AD.