In our study, TCP1 was also confirmed to lead to the accumulation of PUFA-PL on the cell membrane by stabilising the expression of ACSL4; conversely, this strong ferroptotic potential was unblocked when TCP1-overexpressing GCB DLBCL cells were treated with GPX4 inhibitors, resulting in ferroptosis. Here, ACSL4 is linked to diffuse large B-cell lymphoma.